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In 1890, Coley observed that cancer patients who developed infections had smaller tumors. From this, he developed Coley’s toxin and treated tumors with injections of infectious materials. In 1960s, Mahaley used monoclonal antibodies to treat central nervous system(CNS) tumors, that research and clinical investigations in brain tumor immunotherapy became a serious undertaking. ...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1997
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12292070